Benefits
- Key factor in several biological pathways, including methylation reactions, glutathione formation and glutathione S-transferase activity
- Enteric coating protects SAMe degradation from gastric acid, allowing for significantly improved intestinal absorption
- 200 mg SAMe per tablet for flexible-dose titration
- SAMe is produced through a natural fermentation process that yields higher active ingredients over synthetic variations
- Suitable for vegetarians
Feature Summary
S-Adenosyl-L-Methionine (SAMe) has several critical physiological functions and is the common thread between three key metabolic pathways. Well-recognized as a unique methyl donor for more than 100 biological reactions, including DNA methylation. It also links methylation to polyamine synthesis and transsulfuration, which is responsible for cysteine production, the rate-limiting factor in glutathione synthesis.
Quite importantly, it is likely via increases in cartilage formation, glutathione production, DNA methylation, and gene expression which contribute to its efficacy.
Supplement Facts
Medicinal Ingredients
| Each Tablet Contains: | |
| S-Adenosyl-L-Methionine (SAMe) | 200 mg |
Non-Medicinal Ingredients
Microcrystalline cellulose, mannitol, enteric coating (methacrylic acid copolymer, talc, triethyl citrate, glyceryl palmitostearate, silica, titanium dioxide, medium chain triglycerides, yellow iron oxide), glyceryl behenate, vegetable grade magnesium stearate (lubricant), silica, sodium starch glycolate.
Dosage:
Recommended Adult Dose: SAMe should always be taken on an empty stomach.
For mood balance: 1–4 tablets 2 times per day or as directed by a health care practitioner.
For osteoarthritic pain: 1–3 tablets 2 times per day or as directed by a health care practitioner. Do not exceed a total of 8 tablets per day. SAMe must be taken for a minimum of 2 weeks, at which time effects should be observed.
Allergens:
Contains no artificial colours, preservatives, or sweeteners; no dairy, sugar, wheat, gluten, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.